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Microarray Data Interpretation
Ludwig, Petr ; Šilhavá, Jana (referee) ; Smrž, Pavel (advisor)
This Bachelor thesis explains the basics of biochip or microarray data interpretation, starting with short introduction to genetics, especially genetic information significance evaluating. The focus was set mainly on the set of scripts transforming and analyzing the sample data. The data used in this thesis are a result of biochip analysis of the Colon Tumor tissues. The secondary result represents disclosing the main marker for this particular type of cancer, the primary result is evaluation of marker significance in the context of signaling pathways. The resulting pathways are sorted by relevance.
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The role of desmin in a heart
Šeovićová, Maja ; Horníková, Daniela (advisor) ; Vegrichtová, Markéta (referee)
Desmin forms a muscle specific intermediate filament which participates in a formation of a dynamic intracellular network that links contractile apparatus with a sarcolemma, mitochondria and it provides a communication with a cell nucleus. This network serves to maintain morphological and functional aspects of muscle cells and cell organelles during a muscle contraction. Mutation in a desmin or an absence of desmin is causing a serious disease called desminopathy, which belongs among a group of myofibrillar myopathies. This disease manifests itself in all muscle types, however first observable defects occur in cardiac mitochondria, thus heart is a first organ manifesting symptoms of this disease. The purpose of this thesis was to summarize a current knowledge about physiological and molecular mechanisms that involved in a formation of intracellular desmin network and about patho-physiological states of desminopathies. Key words: desmin, intermediate filaments, heart, desminopathy, cardiomyopathy
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The role of desmin in a heart
Šeovićová, Maja ; Horníková, Daniela (advisor) ; Vegrichtová, Markéta (referee)
Desmin forms a muscle specific intermediate filament which participates in a formation of a dynamic intracellular network that links contractile apparatus with a sarcolemma, mitochondria and it provides a communication with a cell nucleus. This network serves to maintain morphological and functional aspects of muscle cells and cell organelles during a muscle contraction. Mutation in a desmin or an absence of desmin is causing a serious disease called desminopathy, which belongs among a group of myofibrillar myopathies. This disease manifests itself in all muscle types, however first observable defects occur in cardiac mitochondria, thus heart is a first organ manifesting symptoms of this disease. The purpose of this thesis was to summarize a current knowledge about physiological and molecular mechanisms that involved in a formation of intracellular desmin network and about patho-physiological states of desminopathies. Key words: desmin, intermediate filaments, heart, desminopathy, cardiomyopathy
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Microarray Data Interpretation
Ludwig, Petr ; Šilhavá, Jana (referee) ; Smrž, Pavel (advisor)
This Bachelor thesis explains the basics of biochip or microarray data interpretation, starting with short introduction to genetics, especially genetic information significance evaluating. The focus was set mainly on the set of scripts transforming and analyzing the sample data. The data used in this thesis are a result of biochip analysis of the Colon Tumor tissues. The secondary result represents disclosing the main marker for this particular type of cancer, the primary result is evaluation of marker significance in the context of signaling pathways. The resulting pathways are sorted by relevance.
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